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Figure 8 | BMC Neuroscience

Figure 8

From: Neural mechanisms of interstimulus interval-dependent responses in the primary auditory cortex of awake cats

Figure 8

A single-cell dynamic model replicates the response kinetics of the synchronization neurons. The simulation was made on various combinations of the receptors (AMPA, GABAA, NMDA and GABAB receptors) with/without frequency-dependent depression (FDD) and paired-pulse facilitation (PPF) (depicted in each panel). Measures were generated by averaging responses over 20 simulations for each condition. A-E: Membrane potentials obtained at ISI of 71 ms (at the best ISI, region β; A), 14.3 ms (region γ; B), 11.8 ms (γ-δ border; C), 5.6 ms (region δ; D) and 164 ms (α-β border; E). F, G: The tMTF (F) and rMTF (G) obtained under various conditions. Measures were filtered by a weighted average with its 5 neighbors in the ratio of 1:2:3:2:1. Gray curve: the mean (with SD) of physiological data for the synchronization type with band-pass tMTF (based on 2A-1 for Fig. 8F, and 2A-2 for Fig. 8G). In F, the broken line denotes statistically significant level (P ≤ 0.05; Rayleigh Z-test) and the arrows indicate β-γ border (open, filled) or α-β border (dotted) in various conditions. See Methods for details.

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