Figure 2
From: Regulation of cerebrospinal fluid production by caffeine consumption
The chronic administration of caffeine increased CSF production and acute administration decreased it. A. The effect of chronic administration of caffeine on Blue Dextran recovery (Cout/Cin) from the CSF throughout a 60-min ventriculocisternal perfusion. The CSF was collected from the cisterna magna beginning immediately after the infusion. B. The effect of chronic administration of caffeine on the CSF production rate. C. The effect of acute administration of caffeine on the CSF production rate. Values are expressed as means ± SEM from 10 rats in each group. *, P < 0.01; **, P < 0.05 versus control rats