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Figure 3 | BMC Neuroscience

Figure 3

From: Mitochondrial BNIP3 upregulation precedes endonuclease G translocation in hippocampal neuronal death following oxygen-glucose deprivation

Figure 3

EndoG nuclear translocation preceded neuronal cell death following reoxygenation. (A-D) Confocal laser scanning microscope images of EndoG immunoreactivity (red) at control, EBSS, OGD/R6 h, OGD/R24 h, respectively. Co-staining with DAPI (blue) allowed the identification of nuclear translocation of EndoG. The white arrow indicates the nucleus with EndoG translocation but without pyknosis, and the white arrowhead indicates the pyknotic nucleus with EndoG translocation; (E) Percentage of damaged neurons and neurons displaying nuclear EndoG at different time points following reoxygenation. *p < 0.05 vs. control group, n = 9.

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