Figure 5From: Non-receptor tyrosine kinase Src is required for ischemia-stimulated neuronal cell proliferation via Raf/ERK/CREB activation in the dentate gyrusSuggested pathways through which Src kinase regulates cell proliferation in the DG after ischemia. Transient global ischemia triggered sustained activation of Src kinase by intracellular Ca2+ influx via NMDA and L-VGCC or released from ER and mitochondria. Subsequently, activated Src induced continuous phosphorylation of ERK through direct phosphorylation of Raf-1 at its Tyr 340/341, and in turn, was translocated from the cytosol to the nucleus where it regulated transcription via CREB and some genes relating to cell proliferation expression.Back to article page