Figure 3

Differential expression of cadherins in central regions of the ferret retina during development. Expression of protocadherin-10 (PCDH10; A), protocadherin-11 (PCDH11; B), protocadherin-17 (PCDH17; C) and protocadherin-18 (PCDH18; D) was mapped with cRNA probes at embryonic day 23 (E23), E30, E38, postnatal day 2 (P2), P13, P25 and at the mature stage (P60). For neuroanatomical orientation, the different layers of the retina are indicated on the right side of each panel. Large arrows point at large ganglion cells (> 15 μm in largest diameter), whereas small arrows point at several cells in the ganglion cell layer (GCL) in D (PCDH18). Large arrowheads point at amacrine cells at the inner margin of the inner nuclear layer (INL), next to the inner plexiform layer (IPL). Small arrowheads point at putative horizontal cells adjacent to the outer plexiform layer (OPL). The outer nuclear layer (ONL) is shown up to the outer limiting membrane and does not include the outer photoreceptor segments after P13. The pigment epithelium next to the neuroblast layer (NBL) is indicated by an asterisk. Scale bar in F, 50 μm, applies to all panels.