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Figure 3 | BMC Neuroscience

Figure 3

From: Voltage-gated sodium channels in taste bud cells

Figure 3

Expression of SCN2A, SCN3A, and SCN9A in taste buds by IHC. A, SCN3A is expressed in a population of CV taste cells. B, SCN3A peptide blocks taste cell labelling. C, SCN2A is expressed in a population of CV taste cells. D, SCN2A peptide blocks taste cell labelling. E-F, SCN2A is also expressed in nerve fibers innervating taste cells. E, Transverse section with SCN2A immunoreactivity prevalent in punctuate nerve fibers (arrows) as well as taste cells. F, Longitudinal section at base of taste bud with SCN2A immunoreactivity in nerve fibers near the basal lamina (dotted white line). G, SCN9A is expressed in a population of CV taste cells. H, SCN9A peptide blocks taste cell labelling. I-K, SCN3A (I), SCN2A (J), and SCN9A (K) are expressed in FG taste cells. Scale bar is 40 μm in A and represents scale for A-D and G-H, 20 μm in E, 5 μm in F, and 25 μm in I-K.

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