Table 1 Parameter changes to simulate stress and ageing
From: A mathematical model of aging-related and cortisol induced hippocampal dysfunction
Ageing Parameter Changes | Default Value | New Value/Comments |
|---|---|---|
khos | 1.6 × 10-6 | 8.1 × 10-6 at 60 years |
|  |  | 5.3 × 10-5 at 80 years |
ktfs | 2.5 × 10-6 | 9 × 10-6 at 60 years |
|  |  | 3.4 × 10-6 at 80 years |
Acute Stress Intervention | Â | Â |
Hippocampus Output Chronic Stress Intervention | Â | Â |
kcor | 2.4 × 10-3 | Increased default value every year by 5.0 × 10-5 from 60–80 years then reduced parameter by 3.24 × 10-5 to mark cessation of chronic stress |
Hippocampus output Acute Stress Intervention | Â | Â |
kcor | 2.4 × 10-3 | Increased default value every year by 3.0 × 10-5 from 60–80 years then reduced parameter by 2.50 × 10-5 to mark cessation of chronic stress |
Hippocampus Output Acute Stress Intervention | Â | Â |
kcor | 2.4 × 10-3 | Increased default value every year by 1.55 × 10-5 from 60–80 years then reduced parameter by 2.50 × 10-5 to mark cessation of acute stress |
Hippocampus output chronic stress intervention | Â | Â |
kcor | 2.4 × 10-3 | Increased default value every year by 2.05 × 10-5 from 60–80 years then reduced parameter by 1.5 × 10-5 to mark cessation of chronic stress |
Hippocampus output with PA intervention for acute stress | Â | Â |
kcor | 2.4 × 10-3 | Decreased value used for acute stress intervention by 2.8 × 10-5 on 60 years 3.0 × 10-6 |
Hippocampus Output with PA intervention for chronic stress | Â | Â |
kcor | 2.4 × 10-3 | Decreased value used for acute stress intervention by 1.0 × 10-5 on 60 years and 80 2.5 × 10-6 |
Hippocampus Volume With PA intervention for chronic stress | Â | Â |
kcor | 2.4 × 10-3 | Decreased value used for acute stress intervention by 5 × 10-8 on 60 years and 80 years 5 × 10-5 |
Hippocampus Volume With PA intervention for acute stress | Â | Â |
kcor | 2.4 × 10-3 | Decreased value used for acute stress intervention by 3.0 × 10-6 on 60 years and 80 8.0 × 10-8 |