From: A mathematical model of aging-related and cortisol induced hippocampal dysfunction
Ageing Parameter Changes | Default Value | New Value/Comments |
---|---|---|
k_{hos} | 1.6 × 10^{-6} | 8.1 × 10^{-6} at 60 years |
5.3 × 10^{-5} at 80 years | ||
k_{tfs} | 2.5 × 10^{-6} | 9 × 10^{-6} at 60 years |
3.4 × 10^{-6} at 80 years | ||
Acute Stress Intervention | ||
Hippocampus Output Chronic Stress Intervention | ||
k_{cor} | 2.4 × 10^{-3} | Increased default value every year by 5.0 × 10^{-5} from 60–80 years then reduced parameter by 3.24 × 10^{-5} to mark cessation of chronic stress |
Hippocampus output Acute Stress Intervention | ||
k_{cor} | 2.4 × 10^{-3} | Increased default value every year by 3.0 × 10^{-5} from 60–80 years then reduced parameter by 2.50 × 10^{-5} to mark cessation of chronic stress |
Hippocampus Output Acute Stress Intervention | ||
k_{cor} | 2.4 × 10^{-3} | Increased default value every year by 1.55 × 10^{-5} from 60–80 years then reduced parameter by 2.50 × 10^{-5} to mark cessation of acute stress |
Hippocampus output chronic stress intervention | ||
k_{cor} | 2.4 × 10^{-3} | Increased default value every year by 2.05 × 10^{-5} from 60–80 years then reduced parameter by 1.5 × 10^{-5} to mark cessation of chronic stress |
Hippocampus output with PA intervention for acute stress | ||
k_{cor} | 2.4 × 10^{-3} | Decreased value used for acute stress intervention by 2.8 × 10^{-5} on 60 years 3.0 × 10^{-6} |
Hippocampus Output with PA intervention for chronic stress | ||
k_{cor} | 2.4 × 10^{-3} | Decreased value used for acute stress intervention by 1.0 × 10^{-5} on 60 years and 80 2.5 × 10^{-6} |
Hippocampus Volume With PA intervention for chronic stress | ||
k_{cor} | 2.4 × 10^{-3} | Decreased value used for acute stress intervention by 5 × 10^{-8} on 60 years and 80 years 5 × 10^{-5} |
Hippocampus Volume With PA intervention for acute stress | ||
k_{cor} | 2.4 × 10^{-3} | Decreased value used for acute stress intervention by 3.0 × 10^{-6} on 60 years and 80 8.0 × 10^{-8} |