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Table 1 Parameter changes to simulate stress and ageing

From: A mathematical model of aging-related and cortisol induced hippocampal dysfunction

Ageing Parameter Changes Default Value New Value/Comments
khos 1.6 × 10-6 8.1 × 10-6 at 60 years
   5.3 × 10-5 at 80 years
ktfs 2.5 × 10-6 9 × 10-6 at 60 years
   3.4 × 10-6 at 80 years
Acute Stress Intervention   
Hippocampus Output Chronic Stress Intervention   
kcor 2.4 × 10-3 Increased default value every year by 5.0 × 10-5 from 60–80 years then reduced parameter by 3.24 × 10-5 to mark cessation of chronic stress
Hippocampus output Acute Stress Intervention   
kcor 2.4 × 10-3 Increased default value every year by 3.0 × 10-5 from 60–80 years then reduced parameter by 2.50 × 10-5 to mark cessation of chronic stress
Hippocampus Output Acute Stress Intervention   
kcor 2.4 × 10-3 Increased default value every year by 1.55 × 10-5 from 60–80 years then reduced parameter by 2.50 × 10-5 to mark cessation of acute stress
Hippocampus output chronic stress intervention   
kcor 2.4 × 10-3 Increased default value every year by 2.05 × 10-5 from 60–80 years then reduced parameter by 1.5 × 10-5 to mark cessation of chronic stress
Hippocampus output with PA intervention for acute stress   
kcor 2.4 × 10-3 Decreased value used for acute stress intervention by 2.8 × 10-5 on 60 years 3.0 × 10-6
Hippocampus Output with PA intervention for chronic stress   
kcor 2.4 × 10-3 Decreased value used for acute stress intervention by 1.0 × 10-5 on 60 years and 80 2.5 × 10-6
Hippocampus Volume With PA intervention for chronic stress   
kcor 2.4 × 10-3 Decreased value used for acute stress intervention by 5 × 10-8 on 60 years and 80 years 5 × 10-5
Hippocampus Volume With PA intervention for acute stress   
kcor 2.4 × 10-3 Decreased value used for acute stress intervention by 3.0 × 10-6 on 60 years and 80 8.0 × 10-8