Table 3 Model Kinetics and Rate Constant Values.
From: A mathematical model of aging-related and cortisol induced hippocampal dysfunction
Abbreviation | Description | Default Values |
|---|---|---|
kcrh | Rate constant for generation of CRH | 3.8 × 10-1 |
kacth | Rate constant for generation of ACTH | 1.085 × 10-1 |
kcor | Rate constant for generation of cortisol | 2.4 × 10-3 |
kcdeg | Rate constant for the degradation of cortisol. | 8.5 × 10-3 |
Vcrh | Saturation level of inhibition for hypothalamic cells | 1 |
Vacth | Saturation level of inhibition for pituitary secretory cells | 1 |
kda | Dissociation constant for cortisol in the hypothalamus | 50 |
kdc | Dissociation constant for cortisol in the pituitary | 50 |
kgr | Concentration of cortisol at which GR receptors are 50% saturated. | 1 × 108 |
kmr | Concentration of cortisol at which MR is 50% of its max | 2.5 × 103 |
kmad | Rate constant for the deactivation of MR receptors | 1 |
knon | Rate constant for the inhibition of CA1 neurons by MR receptors. | 4.99 × 10-2 |
kGRD | Rate constant for degradation of GR activity | 4.45 × 10-1 |
kngf | Rate constant for stimulation of CA1 neurons by growth factors. | 10 × 10-8 |
knps | Rate constant for death of neurons. | 4.5 × 10-2 |
kngfs | Rate constant for neuronal growth factor decline. | 1 |
knbd | Rate constant for stimulation of NBD | 5 × 10-2 |
kses | Rate constant for stimulation of synaptic excitatory signals. | 1.049 |
ksf | Rate constant for stimulation of synaptic firing | 1.049 |
kso | Rate constant for stimulation of synaptic output. | 1.049 |
kho | Rate constant for stimulation of hippocampal output. | 1.049 |
khos | Rate constant for degradation of synaptic output | 5.5 × 104 |
kSI | Rate constant for inhibition of synaptic firing by synaptic inhibitory signals. | 2.2 × 10-1 |
kSGR | Rate constant for production of synaptic inhibitory signals. | 4.45 × 10-1 |
ksos | Rate constant for stimulation of synaptic firing. | 1.049 |
ksisd | Rate constant for decline in synaptic inhibitory signals | 3.8 × 10-1 |
Vcrh | Saturation level of inhibition for hypothalamic cells | 1 |
Vacth | Saturation level of inhibition for pituitary cells | 1 |
VmaxMRA | Maximum rate of activity of MR receptors | 1 × 102 |
VmaxGRA | Maximum rate of activity of GR receptors | 1 × 102 |
Ngr | Hill coefficient for GR receptor Activity | 3.6 |
Nmr | Hill coefficient for MR receptor activity | 5.8 |
HV | Volume of Hippocampus | 100 |