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Table 1 Mean metabolic ratios in each animal group before and after donepezil and NaCl respectively.

From: In vivo 1H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatment

Mice type

Brain region

Treatment

Gln/tCr

Glu/tCr

m-Ins/tCr

Tau/tCr

tCho/tCr

tNAA/tCr

   

Mean ± SD

tg

str

before

0.64 ± 0.11

1.30 ± 0.13

0.96 ± 0.11

1.28 ± 0.10

0.33 ± 0.03

0.90 ± 0.13

tg

str

donepezil

0.77 ± 0.28

1.27 ± 0.34

0.89 ± 0.11

0.97 ± 0.23

0.38 ± 0.01

0.93 ± 0.15

tg

str

NaCl

0.59 ± 0.07

1.47 ± 0.22

0.97 ± 0.13

1.29 ± 0.14

0.39 ± 0.03

0.99 ± 0.07

tg

ctx/hipp

before

0.61 ± 0.13

1.48 ± 0.26

0.62 ± 0.15

0.86 ± 0.10

0.24 ± 0.03

1.19 ± 0.11

tg

ctx/hipp

donepezil

0.72 ± 0.08

1.60 ± 0.30

0.57 ± 0.07

0.73 ± 0.07

0.24 ± 0.03

1.24 ± 0.20

tg

ctx/hipp

NaCl

0.72 ± 0.17

1.60 ± 0.23

0.55 ± 0.14

0.85 ± 0.13

0.25 ± 0.04

1.18 ± 0.21

wt

str

before

0.61 ± 0.14

1.18 ± 0.12

0.78 ± 0.09

1.14 ± 0.10

0.34 ± 0.02

0.88 ± 0.10

wt

str

donepezil

0.67 ± 0.11

1.34 ± 0.16

0.79 ± 0.12

1.22 ± 0.13

0.36 ± 0.02

0.93 ± 0.05

wt

str

NaCl

0.72 ± 0.10

1.25 ± 0.11

0.78 ± 0.09

1.21 ± 0.13

0.34 ± 0.03

0.90 ± 0.06

wt

ctx/hipp

before

0.46 ± 0.16

1.37 ± 0.14

0.52 ± 0.08

0.78 ± 0.08

0.22 ± 0.02

0.96 ± 0.09

wt

ctx/hipp

donepezil

0.49 ± 0.09

1.34 ± 0.11

0.52 ± 0.06

0.75 ± 0.09

0.24 ± 0.03

0.99 ± 0.11

wt

ctx/hipp

NaCl

0.46 ± 0.06

1.41 ± 0.20

0.52 ± 0.09

0.77 ± 0.09

0.22 ± 0.02

1.03 ± 0.10

  1. Abbreviations: Gln = Glutamine, Glu = Glutamate, Tau = Taurine, m-Ins= Myo-inositol, tCho = Choline-containing compounds, tNAA = N-acetylaspartate+N-acetylaspartylglutamate, wt = wild type mice, tg = APP/PS1 transgenic mice, ctx/hipp = parietal cortex/hippocampus, str = striatum.