Figure 3

Covariation of neocortical volume with candidate genes on Chr 11. A. Correlations among expression levels across the BXD RI set of positional candidate genes (blue squares) on Chr 11 and neocortical volume (green squares). Red and orange lines indicate Pearson correlations of > +0.7 and +0.5 to +0.7, respectively. Blue and green lines indicate correlations of < -0.7 and -0.5 to -0.7, respectively. Black lines have correlations between |0.4| and |0.5|. Line thickness varies with strength of correlation. Neocortical volume correlates with these transcripts, and there are strong intercorrelations among the transcripts themselves. B. QTL cluster map of transcripts and phenotypes listed in A. This is a "hot map" of LRS scores, with red indicating modulation by DBA/2J alleles, and blue indicating modulation by C57BL/6J alleles. The enlarged portion of Chr 11 indicates that the 7 transcripts are cis-acting QTLs, i.e., genes that modulated their own expression (orange triangles indicate genetic location of the transcript).