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Table 2 Results of expression analyses by genotype

From: Genes within the serotonergic system are differentially expressed in human brain

      

H-W test

ANOVA

Gene/Marker

 

Genotype

Genotype

Frequency

( N )

Allele

Allele

Frequency

( N)

χ2 value

P

F

P

5-HT2A

 

AA

0.29 (4)

A

0.46 (13)

0.57

0.75

0.02

0.983

A-1438G

 

AG

0.36 (5)

G

0.54 (15)

    
  

GG

0.36 (5)

      
  

N = 14

       

5-HT2C

         

promoter microsatellite

M

Z

0.67 (4)

    

0.02

0.98

  

Z-6

0.33 (2)

      
 

F

Z-6/Z-6

0.14 (1)

Z-6

0.36 (5)

0.84

0.89

0.14

0.933

  

Z-6/Z

0.29 (2)

Z

0.57 (8)

    
  

Z-6/Z+2

0.14 (1)

Z+2

0.07 (1)

    
  

Z/Z

0.43 (3)

      
  

N = 13

       

TPH2

 

GG

0.69 (9)

G

0.85 (22)

0.94

0.33

1.47

0.23

G-703T

 

GT

0.31 (4)

T

0.15 (4)

    
  

N = 13

       

5-HTT

 

SS

0.07 (1)

S

0.39 (11)

0.43

0.81

0.10

0.91

5-HTTLPR

 

SL

0.64 (9)

L

0.61 (17)

    
  

LL

0.29 (4)

      
  

N = 14

       

5-HTT

 

10/10

0.09 (1)

10

0.23 (5)

0.72

0.70

0.02

0.98

Intron 2 VNTR

 

10/12

0.27 (3)

12

0.77 (17)

    
  

12/12

0.64 (7)

      
  

N = 11

       
  1. Genotype frequencies, allele frequencies, results of H-W (Hardy-Weinberg) tests and ANOVA comparisons of gene expression levels (log(10) 2-ΔCt) values for the polymorphic variants are shown. Genotypes of the 5-HT2C marker are split by gender (Males = M; Females = F) since the males are hemizygotic.
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BMC Neuroscience

ISSN: 1471-2202

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