Table 1 Levels of MMP-9 and TIMP-1 protein in the middle cerebral artery after MCAO and after treatment with the MEK1/2 inhibitor U0126 at 0, 6, and 12 hours post occlusion
Middle cerebral artery | |||||
|---|---|---|---|---|---|
Control | MCAO | MCAO + U0126 - 0 h | MCAO + U0126 - 6 h | MCAO + U0126 - 12 h | |
MMP-9 (%) ± SEM | 100 ± 3 | 198 ± 7** | 114 ± 10§ | 113 ± 8§ | 144 ± 5 |
TIMP-1 (%) ± SEM | 100 ± 5 | 191 ± 7** | 137 ± 5 | 100 ± 4§§ | 184 ± 19 |