Figure 4

Aldicarb Sensitivity Assay. (A) Wild type (wt) or worms that constitutively express human amyloid beta in the muscle cells (CL2006) were pre-incubated for 2 hours on plates with or without 2 mM of 5-HT. Aβ worms (CL2006), exhibit a natural resistance to aldicarb, in comparison to wild type controls. Each group contained 30 animals that were placed on 1 mM of aldicarb and scored until death. (B) Aβ worms (CL2006) were fed BB (0.3 μM) then pre-treated with 2 mM of exogenous 5-HT for 2 hrs. BB treatment has no effect on aldicarb sensitivity in transgenic Aβ worms (CL2006) pre-exposed to 5-HT. Data was obtained from three independent experiments. Each group consisted of 30 worms.