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Table 1 Differential peak amplitudes of [Ca2+]i release from different compartment of WT and SOD1 transfected SH-SY5Y cells after multidrugs intervention.

From: Impairment of mitochondrial calcium handling in a mtSOD1 cell culture model of motoneuron disease

 

FCCP

K+FCCP

Thapsi

Thapsi+FCCP

Oligo

Oligo+FCCP

Caffeine

Caffeine+FCCP

WT

0.17 ± 0.03

0.24 ± 0.06

0.04 ± 0.01

0.27 ± 0.09

0.04 ± 0.01

0.22 ± 0.07

0.04 ± 0.01

0.18 ± 0.05

SOD1

0.09 ± 0.02**

0.14 ± 0.03**

0.02 ± 0.01*

0.12 ± 0.02**

0.02 ± 0.01*

0.08 ± 0.03**

0.03 ± 0.01*

0.11 ± 0.02**

  1. Data are expressed as mean ± S.D.
  2. * p < 0.01 and ** p < 0.001 compared with WT transfected SH-SY5Y cells.