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Figure 2 | BMC Neuroscience

Figure 2

From: Erythropoietin overrides the triggering effect of DNA platination products in a mouse model of Cisplatin-induced neuropathy

Figure 2

Recombinant erythropoietin partly preserved the tactile sensitivity. Mice were treated as in Figure 1 and were examined in week 9 for the mechanical sensitivity using the von Frey hair method and recording of the 50% withdrawal threshold. Columns represent group mean ± SEM from repeated measurements of 10 animals per group. Mechanical withdrawal thresholds were significantly reduced in the cisplatin group (p < 0.001, multiple t-test with Bonferroni corrections). The difference between cisplatin + rhEPO vs. control group was also significant (p = 0.026), while the comparison of cisplatin vs. cisplatin + rhEPO group indicated a restoration of the tactile sensitivity but lacked statistical significance (p = 0.313).

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