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Figure 3 | BMC Neuroscience

Figure 3

From: Non-invasive evaluation of nigrostriatal neuropathology in a proteasome inhibitor rodent model of Parkinson's disease

Figure 3

Representative T2W MR images through the striatum (panel A) and midbrain containing the substantia nigra (SN; panel B) to illustrate regional brain atrophy in saline and lactacystin-injected animals. Clear hypertrophy of both the ipsilateral (solid arrows, A) and contralateral (dashed arrows, A) LV can be observed in lactacystin-lesioned animals, compared to saline controls. In the midbrain (panel B) the sub-cortical area containing the SN in the ipsilateral hemisphere appears clearly deformed compared to the intact contralateral hemisphere (solid arrows). Note also the increased CSF signal, suggestive of a volume change in this region. In addition, areas of T2 hypointensity are observed in the SN, but also in extra-nigral nuclei (dashed arrows).

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