EphrinA5 protein distribution in the developing mouse brain

Deschamps, Claire; Morel, Milena; Janet, Thierry; Page, Guylène; Jaber, Mohamed; Gaillard, Afsaneh; Prestoz, Laetitia

doi:10.1186/1471-2202-11-105

BMC Neuroscience

Table 1 EphrinA5 protein distribution in the developing mouse brain

From: EphrinA5 protein distribution in the developing mouse brain

	TELENCEPHALON	DIENCEPHALON	MESENCEPHALON	METENCEPHALON
E12.5	• Olfactory nerve • Neocortex • Piriform cortex • LGE • LGE dz l. v.➤m. d. • MGE dz l. v.➤m. d.	• Preoptic dz l. v.➤m. d. • Preoptic area • Ventral thalamus v. r.➤d. c. • Hypothalamus v. r.➤d. c.	• Mesencephalic tegmentum	• Isthmus • Cerebellum
E14.5	• Olfactory bulb • Neocortex S1 (CP) • Piriform cortex • LGE l. v. r.➤m. d. c. • Subventricular zone	• Preoptic area • Ventral thalamus v. r.➤d. c. • Subthalamic area •Hypothalamus	• Mesencephalic tegmentum • Superior colliculus • Inferior colliculus l.➤m. • Pretectum l. v.➤m. d. • Commissure of superior colliculus	• Isthmus dz • Cerebellar vermis
E16.5	• Olfactory structures: GCL, MCL, olfactory tubercle, lateral olfactory tract • Septum • LGE v. r.➤d. c. • Neocortex (MZ, CP, SP) • Frontal cortex • Parietal cortex (S1) • Insular cortex • Retrosplenial cortex • Piriform cortex • Hippocampus	• Preoptic area • Thalamus v. r.➤d. c. • Hypothalamus	• Mesencephalic tegmentum • Superior colliculus • Inferior colliculus c.➤r.	• Isthmus • Cerebellar vermis • Pons
E18.5	• Olfactory structures: GCL, olfactory tubercle, lateral olfactory tract • Striatum • Nucleus accumbens • Septum l. v.➤m. d. • Lateral migratory stream • Piriform cortex • Insular cortex • Cingulate cortex • Retrosplenial cortex • Perirhinal cortex • Neocortex • Parietal cortex (S1) • Occipital cortex (layers I & V) • Hippocampus (CA1, CA3, DG)	• Thalamus l. d.➤m. v. • Hypothalamus	• Mesencephalic tegmentum • Superior colliculus • Inferior colliculus l. ➤m. • Commissure of superior colliculus	• Cerebellum • Pons
P0	• Olfactory structures: GCL, subventricular zone, olfactory tubercle, lateral olfactory tract • Subventricular zone • Striatum l. v.➤m. d. • Nucleus accumbens • Septum • Parietal cortex • Frontal cortex • Retrosplenial cortex	• Thalamus • Hypothalamus	• Mesencephalic tegmentum • Superior colliculus • Inferior colliculus c.➤r. • Commissure of superior colliculus	• Cerebellum

EphrinA5 was expressed in the same brain regions of the telencephalon, diencephalon, mesencephalon and metencephalon from E12.5, throughout the embryonic development until P0. The intensity of staining was high from E12.5 to E16.5 and then decreased until P0 to become non-existent in P7 animals (data not shown). The names of brain regions exhibiting a strong ephrinA5 protein expression were underlined and highlighted in bold, whereas names of brain structures showing a moderate ephrinA5 protein expression were only underlined. Names of brain regions exhibiting weak or non-existent ephrinA5 protein expression were not highlighted. Black arrowheads indicate ephrinA5 protein expression gradients. Abbreviations: see list.

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ISSN: 1471-2202

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