Figure 1

DNA microarray analysis of RNA isolated from the hippocampus of antidepressant treated rats. A hierarchical clustergram of genes in treated rat hippocampus was obtained from the control and experimental (antidepressnats) group. Specific pathogen-free, 6 week old male SD rats were divided into four groups that were subjected to the following treatments: fluoxetine, imipramine, phenelzine and Nelumbinis Semen. Each group was further subdivided into 3 subgroups (n = 3 per subgroup) that were treated for 1, 3 and 7 days. Fluoxetin (10 mg/kg), imipramine (10 mg/kg) and phenelzine (5 mg/kg) were administrated intraperitoneally, while Nelumbinis Semen (400 mg/kg) was administered orally. The control (Con) group was treated with orally administered saline.