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Figure 1 | BMC Neuroscience

Figure 1

From: Sleep triggered by an immune response in Drosophila is regulated by the circadian clock and requires the NFκB Relish

Figure 1

Infection and injury promote sleep from ZT 0-4 after treatment in wild-type CS flies. (A) Representative results from infection (Inf) with E. coli and aseptic injury (Inj) at ZT 18 (arrow). Mean ± SEM percent time sleeping is plotted for 4 consecutive days in 4 hr increments. Shaded area indicates the increase in sleep from ZT 0-4 after treatment. [n = 12 for Inf; n = 15 for Inj; and n = 16 for handled control group (HC).] (B) Mean ± SEM net changes in sleep are reported from ZT 0-4 the morning after treatment at each of four time points (ZT 0, 6, 12 or 18). p < 0.0001, ANOVA; ** p < 0.01, Tukey's post-hoc comparisons within infected or injured groups. n = 26-61 flies per group. (C) Net changes in sleep from circadian time (CT) 0-4, the subjective morning after treatment in constant darkness, at CT 6 or CT 18. ** p < 0.01 with student's t-test within infected or injured groups. n = 28-32 flies per group. Values for mean net changes in sleep in (B) and (C) and all other subsequent figures, except where otherwise indicated, are normalized to those in handled control groups (see Methods).

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