Figure 6

Survivin^Camcremice exhibit increased seizure activity. (A) Scatter plot showing the maximum seizure score assigned to each experimental animal during a 2 hr observation period following KA administration. Seizure scores were significantly higher in the Survivin^Camcremice as compared to controls. Horizontal bars indicate the mean for each group. (B) KA (20 mg/kg ip) induced signficantly more severe seizure activity in Survivin^Camcremice as compared to controls, P < 0.001, n = 13-16 mice per group. (C, D) Representative NPY-stained coronal sections through the hippocampus of saline-treated control (wt) (C) and Survivin^Camcremice (ko) (D) reveals ectopic NPY expression by mossy fibers in Survivin^Camcremice (arrows in D). (E) Quantification of BrdU⁺ cells (1 day after BrdU injection) in the SGZ from saline and KA treated control and Survivin^Camcremice. The neurogenic response to KA was significantly dampened in Survivin^Camcremice as compared to controls, n = 4-5 mice per group. Results in panels B and E are reflected as means + SEM. **P < 0.001. Scale bars: C-D 500 μm.