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Figure 3 | BMC Neuroscience

Figure 3

From: Acute NMDA toxicity in cultured rat cerebellar granule neurons is accompanied by autophagy induction and late onset autophagic cell death phenotype

Figure 3

NMDA exposure induces the formation of MDC-positive autophagosomes in cerebellar granule neurons. Representative fluorescence micrographs of granule neurons incubated with monodansylcadaverine (MDC) show an increase in the labeling of the autophagosomes in both the neurites and the cell bodies. Arrows and arrow heads (yellow) indicate the normal punctate autophagosome staining at 6 and 12 hours in the cell bodies and neurites, respectively. Red arrows indicate the dense autophagosomes staining in the cell bodies following prolonged exposure to NMDA (12 to 24 hours). All images were taken at 400× magnification. Scale bar represents 10 μm.

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