Figure 5

Effect of bis(7)-tacrine on RGCs following intravitreal injection of glutamate(Glu) (20 nmol). (A) A representative photograph of RGCs labeled with fluorogold injected into the superior colliculus in normal retina. (B) A representative photograph of fluorogold -labeled RGCs 7 days after intravitreal injection of glutamate. (C & D) A representative photograph of fluorogold -labeled RGCs 7 days after intravitreal injection of glutamate with daily peritoneal injection of bis(7)-tacrine(0.2 mg/kg)(C) or memantine(20 mg/kg)(D). (E) The number of RGCs was counted. Each column represents means ± SEM (n = 6). *P < 0.05, **P < 0.01 versus glutamate group alone. Scale bar, 50 μm.