Figure 5
From: Dynamics of peptidergic secretory granule transport are regulated by neuronal stimulation
Secretagogues increase linearity but not cumulative velocity in axons. LDCVs containing PHM-GFP were imaged in the presence of PMA or KCl; the effects of secretagogue on dynamics were compared to behaviors observed under basal conditions. LDCV velocity and linearity were assessed in axons; data for each treatment group were pooled from 6 cells each. The distribution of cumulative velocity (A) and linearity (B) is shown for LDCVs under basal conditions and during stimulation with PMA and KCl. Both PMA and KCl had a significant effect (p < 0.01) on linearity, but not on velocity.