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Table 3 Methodological comparison of previous and present study

From: Different methods for administering 17β-estradiol to ovariectomized rats result in opposite effects on ischemic brain damage

Methodological parameter

Theodorsson & Theodorsson 2005

Present study

Estrogen administration mode

Pellets from Innovative Research of America

Home-made silastic capsules

Length of estrogen treatment

2 weeks

Type of estrogen

17β-estradiol

Method for induction of ischemic lesions

MCAo by microclip, reperfusion after 60 min

Length of time between ischemia and damage evaluation

72 hours

Type of outcome measure

TTC-staining and infarct size measurement

Rat sex

Female

Rat strain

Sprague-Dawley

Rat age

3 months

Rat diseases

None

Miscellaneous

Same laboratory, surgeon and technical equipment used in both studies

Effect of 17β-estradiol on cerebral ischemia

Neurodamage (p < 0.001)

Neuroprotection (p = 0.015)