Methodological parameter | Theodorsson & Theodorsson 2005 | Present study |
---|---|---|
Estrogen administration mode | Pellets from Innovative Research of America | Home-made silastic capsules |
Length of estrogen treatment | 2 weeks | |
Type of estrogen | 17β-estradiol | |
Method for induction of ischemic lesions | MCAo by microclip, reperfusion after 60 min | |
Length of time between ischemia and damage evaluation | 72 hours | |
Type of outcome measure | TTC-staining and infarct size measurement | |
Rat sex | Female | |
Rat strain | Sprague-Dawley | |
Rat age | 3 months | |
Rat diseases | None | |
Miscellaneous | Same laboratory, surgeon and technical equipment used in both studies | |
Effect of 17β-estradiol on cerebral ischemia | Neurodamage (p < 0.001) | Neuroprotection (p = 0.015) |