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Table 2 Top 20 Genes Up-regulated Following Injury

From: Intrinsic response of thoracic propriospinal neurons to axotomy

Probe ID

Gene Symbol

Gene Title

Max Log2 Δ

Known/Presumed Function *

10775731

Cxcl13

Chemokine (C-X-C motif) ligand 13

2.88

Immune

10728924

Ms4a6b

Membrane-spanning 4-domains, subfamily A, member 6B

2.57

Cell Signaling

10761128

Hspb1

Heat shock protein 27

2.50

Cell Survival

10821016

Ccnb1

Cyclin 1B

2.43

Cell Cycle

10779673

Lgals3

Lectin, galactose binding, soluble 3

2.33

Immune

10804463

Lox

Lysyl oxidase

2.32

ECM Modification

10770710

Atf3

Activating transcription factor 3

2.26

Transcription

10720565

Hcst

Hematopoietic cell signal transducer

2.22

Immune

10931222

Emr1

EGF-like module contaning, mucin-like, hormone receptor-like sequence 1

2.06

Cell-Cell Interaction

10710627

Plk1

Polo-like kinase 1

2.02

Cell Cycle

10813392

Fyb

FYN binding protein

2.00

Immune

10785479

Diaph3

Similat to Protein diaphanous homolog 3

1.99

Actin-Cytoskeletal

10865329

Apobec1

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1

1.98

Transcription Modification

10844331

Lcn2

Lipocalin 2

1.97

Inflammatory

10711268

Itgam

Integrin alpha M

1.95

Immune

10814430

Cp

Ceruloplasmin

1.93

Development and Homeostasis

10769771

Fcgr2b

Fe fragment of IgG, low affinity Ilb, receptor

1.89

Immune

10936899

Cybb

Cytochrome b-245, beta polypeptide

1.85

Immune

10838733

Casc5

Similar to cancer susceptibility candidate 5

1.83

Kinetochore Formation

10858559

Clec4a3

C-type lectin domain family 4, member a3

1.82

Immune

  1. Top 20 TPS neuron genes found to be up-regulated following a T9 complete transection. Examination of the genes found to be up-regulated revealed a majority of them to be involved with either the inflammatory or immune response. This list has the genes ranked according to their log2 change, and has been edited from the overall master list (Supplementary Data, Table S1) to exclude non-coding RNA sequences. (*) Known/presumed functions were obtained from the Crown Human Genome Center & Weizmann Institute of Science website GeneCards® which can be accessed at http://www.genecards.org/index.shtml