Skip to main content

Table 3 Top 20 Genes Down-Regulated Following Injury

From: Intrinsic response of thoracic propriospinal neurons to axotomy

Probe ID

Gene Symbol

Gene Title

Max Log2 Δ

Known/Presumed Function *

10803692

Nrep

Neuronal regeneration related protein

-1.70

Nerve Outgrowth

10857916

Slc6a11

Solute carrier family 6 (neurtransmitter transporter GABA), member 11

-1.40

Neurotransmitter Uptake

10888931

Abhd1

Abhydrolase domain containing 1

-1.19

Multiple Enzymatic

10862194

LOC679835

Similar to Anionic trypsin II precursor gene

-1.18

Uncharacterized

10722918

Rlbp1

Retinaldehyde binding protein 1

-1.14

Visual Cycle

10825100

Car14

Carbonic Anhydrase 14

-1.12

Homeostasis

10905284

Tst

Thiosulfate sulfurtransferase

-1.00

Fe-S Complex Formation

10872473

Fabp3

Fatty acid binding protein 3, muscle and heart

-0.89

Fatty Acid Transport

10765740

Kcnj10

Potassium inwardly-rectifying channel, subfamily J, member 10

-0.86

Voltage Gates

10742645

Slc22a5

Solute carrier family 22 (organic cation/carnitine transporter), member 5

-0.83

Carnitine Transporter

10893412

Olr1063

Olfactory receptor 1063

-0.83

Uncharacterized

10782144

Clybl

Citrate lyase beta like

-0.82

Citrate Lyase Activity

10906608

Slc38a2

Solute carrier family 38, member 2

-0.81

Amino Acid Transporter

10706134

Slc7a10

Solute carrier family 7 (neutral amino acid transporter, y+ system), member

-0.80

Glutamatergic Neurotransmitter Modulation

10805605

Dok6

Docking protein 6

-0.80

Neurite Outgrowth

10896666

RGD1311362

Similar to hypothetical protein FLJ10204

-0.79

Uncharacterized

10822735

Pex51

Peroxisomal biogenesis factor 5-like

-0.78

Peroxisomal Targeting

10785773

Spry2

sprouty homolog 2

-0.77

FGF Antagonist

10721796

Lin7b

Lin-7 homolog b

-0.72

Channel and Receptor Localization

10878210

Kank4

KN motif and ankyrin repeated domains 4

-0.72

Actin Stress Fiber Formation

  1. Top 20 down-regulated genes encompass broad functions of cell biology with no one specific function being heavily represented. This list has the genes ranked according to their log2 change, and has been edited from the overall master list (Supplementary Data, Table S1) to exclude non-coding RNA sequences. (*) Known/presumed functions were obtained from the Crown Human Genome Center & Weizmann Institute of Science website GeneCards® which can be accessed at http://www.genecards.org/index.shtml