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Figure 4 | BMC Neuroscience

Figure 4

From: Lipopolysaccharide-induced inflammation attenuates taste progenitor cell proliferation and shortens the life span of taste bud cells

Figure 4

LPS inhibits renewal and shortens average turnover period of taste bud cells. A, Time course of the number of BrdU-labeled taste cells per circumvallate taste bud profile of PBS- or LPS-treated mice. Solid lines indicate the time course curves. Dashed lines show where the numbers of BrdU-labeled taste cells reached half-maximum values for each group. The left and right numbers above the dashed lines are the average times for cells to enter the taste buds (2.5 days for the PBS group and 3 days for the LPS group) and the average taste bud cell turnover periods (12 days for the PBS group and 10 days for the LPS group). LPS treatment slowed the entry of taste bud cells and shortened their turnover period. B, Entry of BrdU-labeled cells into taste buds on days 1-3 after BrdU injection. LPS treatment decreased the number of BrdU-labeled cells per taste bud profile compared with controls. Error bars indicate SEM. * p < 0.05; ** p < 0.005.

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