Figure 2

Synteny between kcnc3a on zebrafish chromosome 3 and Kcnc3 on mouse chromosome 7. Using Synteny Database, synteny in the vicinity of Kv3.3 genes was analyzed using zebrafish (Zv8) as the source genome and mouse (m37) as the outgroup [24, 25]. The strongest synteny (greatest number of orthologous gene pairs) occurred between the segments of zebrafish chromosome 3 and mouse chromosome 7 that contain the kcnc3a and Kcnc3 genes, respectively. The approximate positions of kcnc3a and Kcnc3 are marked in red. Other orthologous pairs of genes are connected by lines. Subclusters of genes identified during the same pass of the sliding window are indicated using lines of the same color. Non-paired genes are not shown. The figure depicts the relative locations of genes but is not drawn to physical scale. Synteny was also detected between the regions of zebrafish chromosome 24 and mouse chromosome 7 that contain kcnc3b and Kcnc3, respectively (data not shown).