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Learning probabilistic models of connectivity from multiple spike train data

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Neuronal circuits or cell assemblies carry out brain function through complex coordinated firing patterns [1]. Inferring topology of neuronal circuits from simultaneously recorded spike train data is a challenging problem in neuroscience. In this work we present a new class of dynamic Bayesian networks to infer polysynaptic excitatory connectivity between spiking cortical neurons [2]. The emphasis on excitatory networks allows us to learn connectivity models by exploiting fast data mining algorithms. Specifically, we show that frequent episodes help identify nodes with high mutual information relationships and can be summarized into a dynamic Bayesian network (DBN).

We model the spike train data as binary random variables and learn high mutual information parent sets of neurons that excite the spiking of down-stream neurons at variable delays. Thus we can express the probability of spiking of each neuron conditioned on the activity of a subset of relevant neurons in recent past (or history window). We formally establish a connection between efficient frequent episode mining algorithms (used to indentify frequently repeating patterns of spiking activity [3]) and learning probabilistic models for excitatory connections. This framework is depicted in Figure 1.

Figure 1
figure1

A multi-electrode array (MEA; left) produces a stream of action potentials (middle). Mining frequent episodes of firing in simultaneously recorded multiple-spike train data uncovers excitatory circuits (right).

We demonstrate the effectiveness of our method in discovering connectivity information on synthetic and real datasets. Our synthetic data generation models each neuron as an inhomogeneous Poisson process whose firing rate is modulated by the input received by the neuron in recent past. The network inter-connect allows us to model complex higher-order interactions. We also demonstrate the application of our method on multi-electrode arrays recordings from dissociated cortical cultures gathered by Steve Potter's laboratory at Georgia Tech [4].

Conclusion

Existing data analysis tools like cross-correlograms, JPSTH and PCA do not scale well as we look at several neurons at a time. Our approach provides an efficient and formal basis for learning probabilistic models from observed spike train data. Several types of network dynamics like syn-fire chains, polychrony [5] etc. that neuronal networks are known to exhibit can be modeled as excitatory networks and hence their putative structure can be learnt using our method (as illustrated in Figure 2). Our proposed approach also scales very well to large data sizes as it marries fast data mining style algorithms with formal model learning.

Figure 2
figure2

Dynamic Bayesian Network models for Syn-fire chains (left) and Polychronous circuits (right).

References

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    Abeles M, Gerstein GL: Detecting spatiotemporal firing patterns among simultaneously recorded single neurons. J Neurophysiol. 1988, 60 (3): 909-924.

  2. 2.

    Patnaik D, Laxman S, Ramakrishnan N: Discovering excitatory networks from discrete event streams with applications to neuronal spike train analysis. Proc. of IEEE Intl. Conf. Data Mining, ICDM. 2009

  3. 3.

    Patnaik D, Sastry PS, Unnikrishnan KP: Inferring neuronal network connectivity from spike data: A temporal data mining approach. Scientific Programming. 2007, 16 (1): 49-77.

  4. 4.

    Wagenaar DA, Pine J, Potter SM: An extremely rich repertoire of bursting patterns during the development of cortical cultures. BMC Neuroscience. 2006

  5. 5.

    Izhikevich EM: Polychronization: Computation with spikes. Neural Comput. 2006, 18 (2): 245-282. 10.1162/089976606775093882.

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Author information

Correspondence to Debprakash Patnaik.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Patnaik, D., Laxman, S. & Ramakrishnan, N. Learning probabilistic models of connectivity from multiple spike train data. BMC Neurosci 11, P171 (2010) doi:10.1186/1471-2202-11-S1-P171

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Keywords

  • Mining Algorithm
  • Dynamic Bayesian Network
  • Data Generation Model
  • Binary Random Variable
  • Inhomogeneous Poisson Process