Inhibition of cerebrovascular raf activation attenuates cerebral blood flow and prevents upregulation of contractile receptors after subarachnoid hemorrhage

Table 4 Contractile effects of Ang II in MCA

	N	K⁺ mean ± s.e.m	E_max (%) ± s.e.m	pEC₅₀ ± s.e.m
Ang II after PD123319 MCA
Sham	6	2.34 ± 0.38	3 ± 2^a
SAH	6	1.33 ± 0.28	53 ± 12^a,b	7.95 ± 0.38
SAH + SB386023-b at 0 h SAH + SB386023-b after 6 h	6 6	1, 74 ± 0.11 1.64 ± 0.12	11 ± 4^b 13 ± 5^b
SAH + SB386023-b after 12 h	6	1.47 ± 0.54	35 ± 5	8, 69 ± 0.14

Responses were characterized by E_max values, expressed as percent of 63 mM K⁺ -induced contraction, and pEC₅₀ values (negative logarithm of the molar concentration that produces half maximum contraction). Values are represented as mean ± s.e.m and n represents number of animal. ^a = significant difference between SAH and control groups, ^b = significant difference between SAH and SAH treated with SB386023-b

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