Table 1 Candidates genes for FTO-interaction studies based on results from queries in Funcoup, Coxpresdb and IntAct (see Figure 1).
Candidate genes | Name | Function |
|---|---|---|
PFN2 | Profilin 2 | Regulates actin polymerization in response to extracellular signals |
NRTK2 | Neurotrophic tyrosine kinase receptor type 2 | Receptor for BDNF |
BDNF | Brain derived neurotrophic factor | involved in neuronal plasticity & differentiation |
PRKACB | cAMP dependent protein kinase catalytic subunit beta | Ser/Thr protein kinase, catalytic subunit of AMP-activated protein kinase (AMPK) |
VAMP2 | Vesicle-associated membrane protein 2. alt. Synaptobrevin-2 | Involved in the targeting and/or fusion of transport vesicles to their target membrane. |
STAT3 | Signal transducer and activator of transcription 3 | Transcription factor involved in cell growth and apoptosis. Responds to leptin signalling. |
NLN | Neurolysin | Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A |
BTBD12 | SLX4 structure-specific endonuclease subunit homolog | DNA-repair, endonuclease activity. |
ZBTB20 | Zinc finger and BTB domain-containing protein 20 | May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses |
ATF7IP | Activating transcription factor 7-interacting protein | A regulator of telomerase reverse transcriptase (TERT) expression |