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Figure 3 | BMC Neuroscience

Figure 3

From: Heightened inflammasome activation is linked to age-related cognitive impairment in Fischer 344 rats

Figure 3

Aging induces alterations in protein expression patterns of Caspase-1, pannexin-1 and P2X7R in hippocampal neurons. Confocal images show hippocampal neurons in the CA3 region of young and aged animals. Sections were stained for caspase-1, pannexin-1 and P2X7 (red) and the neuronal marker NeuN (green). In aged animals, the immunoreactivity of caspase-1, P2X7 and pannexin-1 are increased in neurons of the hippocampus compared to young animals with P2X7 and pannexin-1 showing a polarized distribution near the somatic membrane (arrows). Bar=20 μm.

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