Figure 1
From: Role of TRP channels in dendritic integration and subthreshold membrane potential plateaus
The membrane voltage (Vm) is resting close to -70 mV. At the arrival of an excitatory synaptic stimulus, Vm enters a more depolarized, subthreshold plateau, which is stable to weak inhibitory input (t = 3000 ms). Vm returns to its resting state only if strong inhibitory input is applied (t = 6000 ms). This intrinsic upstate is due to the dynamical balance between the calcium concentration, Vm and calcium, TRP and outward currents.