- Poster presentation
- Open Access
Sensitivity analysis to explain the excitability in a pyramidal neuron with application to Alzheimer’s disease
© Nowacki et al; licensee BioMed Central Ltd. 2011
- Published: 18 July 2011
- Pyramidal Neuron
- Pyramidal Cell
- Parameter Sensitivity
- Model Behaviour
- Profound Impact
Intrinsic excitability is one of the pillars of neuronal behaviour . Combined experimental and modelling studies of neuronal excitability often provide an important insight into the brain functions. In this work we analyse a unified model that we derived for CA1/3 pyramidal neurons in Hodgkin-Huxley formalism . We explore the variations of the model behaviour through parameter sensitivity analysis. Model validation against the experimental current clamp data shows that our model reproduces the behaviour of pyramidal cells very well. A characteristic feature of CA1/3 pyramidal cell response is a higher frequency of the first spike pairs. We define an excitability measure that quantifies parameter sensitivity in our model and takes into account this unique feature of the response.
- Nowacki J, Osinga HM, Brown JT, Randall AD, Tsaneva-Atanasova KT: A unified model of CA1/3 pyramidal cells: An investigation into excitability. Progress in biophysics and molecular biology. 2010, Available http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/pubmed/20887748.Google Scholar
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.