- Poster presentation
- Open Access
Cortical modulation of neuronal activity in the cat's lateral geniculate and perigeniculate nuclei: a modeling study
© Rogala et al; licensee BioMed Central Ltd. 2011
- Published: 18 July 2011
- Spontaneous Activity
- Synaptic Weight
- Lateral Geniculate Nucleus
- Inhibitory Neuron
- Principal Cell
The role of cortical feedback in thalamo-cortical processing loop have been extensively investigated over the last decades. In general, these studies focused on cortical feedback exerted over lateral geniculate nucleus (LGN) principal cells, only in several cases the effects of cortical inactivation were investigated simultaneously in both thalamic relay cells and perigeniculate nucleus (PGN) inhibitory neurons. In the previous study  we showed in the cat that cessation of cortical input by cooling of visual cortex (areas 17 and 18) decreased spontaneous activity of LGN relay cells and increased spontaneous activity of PGN neurons. In contrast, visually evoked responses of most PGN neurons and LGN principal cells both decreased.
To identify network mechanisms underlying such functional changes we conducted a modelling study in NEURON on several networks of point neurons with varied model parameters, such as membrane properties, synaptic weights and axonal delays. We considered five network topologies of the retino-geniculo-cortical pathway [2–6].
Mean spontaneous activity (spikes/s) for tested models (mean of 30 repetitions) and t-test P values.
- Waleszczyk WJ, Bekisz M, Wróbel A: Cortical modulation of neuronal activity in the cat’s lateral geniculate and perigeniculate nuclei. Experimental neurology. 2005, 196 (1): 54-72. 10.1016/j.expneurol.2005.07.006.View ArticlePubMedGoogle Scholar
- Ahlsen G, Lindstrom S, Lo FS: Interaction between inhibitory pathways to principal cells in the lateral geniculate nucleus of the cat. Experimental Brain Research. 1985, 58: 134-143. 10.1007/BF00238961.View ArticlePubMedGoogle Scholar
- Huguenard J, McCormick DA: Thalamic synchrony and dynamic regulation of global forebrain oscillations. Trends in Neurosciences. 2007, 30 (7): 350-6. 10.1016/j.tins.2007.05.007.View ArticlePubMedGoogle Scholar
- Einevoll GT, Plesser HE: Linear mechanistic models for the dorsal lateral geniculate nucleus of cat probed using drifting-grating stimuli. Network. 2002, 13 (4): 503-30. 10.1088/0954-898X/13/4/305.View ArticlePubMedGoogle Scholar
- Hillenbrand U, van Hemmen JL: Does corticothalamic feedback control cortical velocity tuning?. Neural computation. 2001, 13 (2): 327-55. 10.1162/089976601300014565.View ArticlePubMedGoogle Scholar
- Wörgötter F, Nelle E, Li B, Funke K: The influence of corticofugal feedback on the temporal structure of visual responses of cat thalamic relay cells. Journal of Physiology. 1998, 509: 797-815. 10.1111/j.1469-7793.1998.797bm.x.PubMed CentralView ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.