Effects of Stochastic Inputs on Calcium-Dependent Synaptic Plasticity
© Talasila et al; licensee BioMed Central Ltd. 2011
Published: 18 July 2011
Activity dependent potentiation and depression in synaptic efficacy is thought to be one of the underlying mechanisms of learning and memory. Recent studies have shown that moderate increase in synaptic spine calcium concentration leads to synaptic depression, while large increase results in potentiation . We produced a computational model of a small CA3 hippocampal network of cells governed by calcium dependent plasticity developed by  to investigate the effects of i) stochastic network inputs (SNI) and ii) spontaneous cell activation (SCA) on the Ca dependent model of plasticity.
We used a small hippocampal network model consisting of 72 pyramidal cells and 16 interneurons, where each cell was a modified version of the Traub model [3, 4]. The calcium-dependent plasticity model was implanted to govern the changes in synaptic efficacy between the cells. The presence of spontaneous activation of AMPA, NMDA, GABAA and GABAB synaptic elements were varied between zero (low) and 5,5,3,3 Hz (high) respectively. The cells were also provided with SNI that had a Poisson distribution with an expected value of spike per second of either 10(low) or 100(high). The effects of the rate of, SNI and SCA on synaptic plasticity were studied.
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