Physiological and behavioral similarities between KalSRKO/KOand WT mice. A. Blood pressure was measured in conscious animals using the tail-cuff method (CODA-2, Kent Scientific, Torrington, CT). Mice were trained for three days and on the fourth day BP recordings were made. Each measurement consisted of 5 acclimatization cycles followed by 15 BP measurements cycles; data for male and female mice did not differ and were pooled. There were no significant differences in the BP of WT and KalSRKO/KO mice; error bars are S.E.M. B. Sera from male and female mice collected under basal conditions or after restraint stress (15 min) were subjected to PHM assay. Data for males and females did not differ and no significant differences were found between WT and KalSRKO/KO mice; error bars are S.E.M. C. Serum corticosterone levels were measured in male and female mice under basal conditions and after a 15 min restraint stress; data for male and female mice are shown separately. No significant differences were found between genotypes; error bars are S.E.M. D. In the open field, WT and KalSRKO/KO mice (males and females behaved similarly) showed time dependent decreases in spontaneous locomotor activity (F(8,208)=32.91 p<0.001), with no significant difference between genotypes over the 45 min test.