Figure 8

KalSR^KO/KOmice show loss of muscle strength, coordination and stamina. A. After three training days, male and female mice were placed onto an accelerating rotarod, and time to fall from the rotarod was recorded for 3 successive trials separated by 20 min. KalSR^KO/KO mice stayed on the rotarod for less time than WT or Kal^+/KO mice (F(2,35)=39.68: p<0.0001). Bonferroni corrected t-tests revealed a significant difference between all genotypes. B. In the wire hang test, both KalSR^KO/KO and Kal^SR+/KO mice spent less time suspended than WT mice (F(2,32)=35.42, P<0.001). C. In the rotarod test, the performance of Kal^NesKO/NesKO mice was impaired compared to control KalSR^CKO/CKO mice (p<0.01). Kal7^KO/KO mice showed no impairment compared to WT controls. D. In the wire hang test, Kal^NesKO/NesKO mice and control KalSR^CKO/CKO mice spent equal amounts of time suspended. Kal7^KO/KO mice spent more time suspended than WT mice (p<0.01). Data for male and female mice were combined for the rotarod and wire hang tests.