Figure 2

Direct comparison between T0 and follow-up in ALS patients. Comparison of FA results between T0 and follow-up (n=15) with paired t-test superimposed on the mean of all subjects of spatially normalized anisotropy images. FA is significantly reduced in the follow-up in the precentral gyrus, CST (at the mesencephal level), in the cerebellum (culmen, declive), the temporal and parietal lobe (p < 0,001 uncorrected). Comparison of ADC results between T0 and follow-up (n=15) with paired t-test superimposed on the mean of all subjects of spatially normalized anisotropy images. Diffusivity is significantly enhanced after 6 months in the internal and external capsule (p < 0,001 uncorrected).