Table 2 Results of group comparisons of ALS patients versus controls
From: Longitudinal diffusion tensor imaging in amyotrophic lateral sclerosis
| Â | Side | Cluster size | x | y | z | T | p |
|---|---|---|---|---|---|---|---|
T0 FA all ALS patients (n=24) < controls | Â | Â | Â | Â | Â | Â | Â |
Corpus Callosum | l | 7954 | -10 | -14 | 29 | 6.03 | 0.002 |
Corpus Callosum | l | Â | -1 | -16 | 25 | 5.35 | 0.003 |
Corpus Callosum | r | Â | 11 | -16 | 29 | 5.29 | 0.003 |
Brainstem, Pons, CST | l | 1589 | -8 | -27 | -34 | 5.82 | 0.002 |
Brainstem, Pons, CST | r | Â | 9 | -26 | -36 | 4.54 | 0.007 |
Brainstem, Pons, CST | r | Â | 10 | -22 | -24 | 3.88 | 0.027 |
Precentral Gyrus, WM | r | 2386 | 14 | -21 | 58 | 5.69 | 0.002 |
subgyral, WM, Corona Radiata | r | Â | 27 | -38 | 50 | 4.02 | 0.021 |
Medial Frontal Gyrus, WM, below BA 6 | l | 743 | -12 | -13 | 70 | 5.03 | 0.003 |
Precentral Gyrus, WM | r | 290 | 48 | 4 | 8 | 4.59 | 0.007 |
Corona Radiata, Medial Frontal Gyrus, below BA 6 | l | 687 | -35 | -12 | 48 | 4.37 | 0.01 |
Precentral Gyrus, WM | l | Â | -39 | -19 | 48 | 4.18 | 0.015 |
subgyral, WM, below Gyrus postcentralis | l | 201 | -10 | -37 | 61 | 4.35 | 0.011 |
Precentral Gyrus, subgyral, WM, Corona Radiata | l | 343 | -42 | -15 | 23 | 4.34 | 0.011 |
Precentral Gyrus, WM | l | 942 | -28 | -24 | 55 | 4.26 | 0.013 |
Frontal Lobe, subgyral, WM, Corona radiata | l | Â | -17 | -24 | 55 | 3.62 | 0.042 |
Frontal Lobe, subgyral, WM, Corona radiata | r | 345 | 33 | -8 | 38 | 3.87 | 0.028 |
Frontal Lobe, Precentral Gyrus, WM, Corona radiata | l | 309 | -39 | -6 | 35 | 3.86 | 0.028 |
Frontal Lobe, Precentral Gyrus, BA 6 | l | Â | -46 | 1 | 40 | 3.82 | 0.03 |
Limbic Lobe, Parahippocampal Gyrus, WM | l | 218 | -20 | -48 | -11 | 3.80 | 0.032 |
T0 ADC all ALS patients (n =24) > controls | Â | Â | Â | Â | Â | Â | Â |
Precentral Gyrus, WM | l | 5108 | -9 | -25 | 67 | 5.99 | 0.02 |
Precentral Gyrus, subgyral, WM, below BA 6 | l | Â | -28 | -16 | 65 | 5.5 | 0.02 |
Frontal Lobe, subgyral, WM, Corona radiata | l | Â | -28 | -25 | 50 | 5.33 | 0.02 |
Precentral Gyrus, subgyral, WM | r | 5537 | 21 | -16 | 65 | 5.56 | 0.02 |
Precentral Gyrus, WM | r | Â | 11 | -23 | 67 | 5.22 | 0.02 |
Frontal Lobe, subgyral, WM, Postcentral Gyrus | r | Â | 15 | -34 | 61 | 4.31 | 0.031 |
Brainstem, Pons | r | 3243 | 6 | -22 | -28 | 5.13 | 0.02 |
Brainstem, Pons | l | Â | -4 | -23 | -28 | 4.21 | 0.034 |
Limbic Lobe, Parahippocampal Gyrus, WM | r | Â | 26 | -14 | -14 | 3.98 | 0.041 |
Temporal Lobe, Superior Temporal Gyrus, GM | l | 547 | -62 | -12 | -1 | 4.90 | 0.02 |
Parietal Lobe, Superior Parietal Lobule, subgyral, BA 7 | r | 754 | 21 | -50 | 65 | 4.73 | 0.022 |
Precentral Gyrus, WM | r | 336 | 47 | -2 | 31 | 4.55 | 0.025 |
Postcentral Gyrus, subgyral, WM | l | 645 | -18 | -32 | 71 | 4.22 | 0.034 |
Postcentral Gyrus, subgyral, WM | l | Â | -27 | -31 | 67 | 4.02 | 0.04 |
Frontal Lobe, Superior Frontal Gyrus, GM, BA 9 | l | 467 | -22 | 42 | 39 | 4.15 | 0.036 |
Frontal Lobe, subgyral, WM | l | Â | -25 | 39 | 29 | 3.78 | 0.046 |
Temporal Lobe, subgyral, WM | l | 409 | -32 | 9 | -35 | 4.11 | 0.037 |
Frontal Lobe, Superior Frontal Gyrus, WM | r | 269 | 5 | 20 | 53 | 4.02 | 0.04 |
Frontal Lobe, Medial Frontal Gyrus, GM, BA 8 | l | 383 | -6 | 27 | 53 | 4.02 | 0.04 |
Limbic Lobe, Uncus, WM | r | 827 | 22 | -3 | -36 | 3.95 | 0.041 |
Limbic Lobe | r | Â | 22 | -8 | -43 | 3.68 | 0.049 |
Frontal Lobe, Precentral Gyrus, subgyral, WM | l | 231 | -51 | -3 | 23 | 3.91 | 0.042 |
Sub-lobar, Insula, WM | l | 208 | -40 | -17 | 19 | 3.89 | 0.043 |
Frontal Lobe, Superior Frontal Gyrus, GM | l | 233 | -22 | 10 | 57 | 3.88 | 0.043 |
Frontal Lobe, Middle Frontal Gyrus, GM, BA 8 | l | 217 | -23 | 20 | 50 | 3.87 | 0.043 |
Frontal Lobe, Middle Frontal Gyrus, GM, BA 10 | r | 365 | 27 | 53 | 26 | 3.81 | 0.045 |
Frontal Lobe, Superior Frontal Gyrus, GM, BA 9 | r | Â | 24 | 45 | 39 | 3.71 | 0.048 |
Follow-up FA all ALS patients (n =15) < controls | Â | Â | Â | Â | Â | Â | Â |
Precentral Gyrus, subgyral, WM, Corona radiata | r | 293 | 48 | 4 | 6 | 6.26 | 0.017 |
Corpus Callosum | l | 3260 | -8 | -18 | 28 | 5.70 | 0.017 |
Corpus Callosum | r | Â | 11 | -17 | 28 | 4.8 | 0.026 |
Left Brainstem, Pons | l | 218 | -6 | -28 | -38 | 5.02 | 0.02 |
Limbic Lobe, Parahippocampal Gyrus, WM | l | 1004 | -22 | -42 | -10 | 4.89 | 0.023 |
Temporal Lobe, Fusiform Gyrus, GM, BA 37 | l | Â | -27 | -37 | -16 | 4.26 | 0.04 |
Sub-lobar, Thalamus, GM, Pulvinar | l | 217 | -13 | -33 | 1 | 4.51 | 0.033 |
Frontal Lobe, Medial Frontal Gyrus, WM, Corona radiata | r | 696 | 13 | -26 | 58 | 4.44 | 0.035 |
Frontal Lobe, Medial Frontal Gyrus, WM, Corona radiata | r | Â | 9 | -27 | 69 | 4.28 | 0.04 |
parahippocampal Amygdala | r | 206 | 29 | -30 | -26 | 4.36 | 0.037 |
Limbic Lobe, Parahippocampal Gyrus, GM, BA 34 | r | 204 | 17 | -7 | -19 | 4.20 | 0.043 |
Follow-up ADC all ALS patients (n =15) > controls | Â | Â | Â | Â | Â | Â | Â |
Precentral Gyrus, WM | r | 3258 | 24 | -20 | 63 | 6.18 | 0.036 |
Precentral Gyrus, subgyral, WM | r | Â | 12 | -21 | 62 | 5.01 | 0.001* |
Precentral Gyrus, subgyral, WM, Corona radiata | r | Â | 18 | -20 | 43 | 4.1 | 0.013* |
Sub-lobar, Extra-Nuclear, WM, Internal capsule, Crus post. | r | 379 | 18 | -13 | -1 | 4.32 | 0.008* |
Sub-lobar, Extra-Nuclear, WM, Internal capsule, Crus post. | l | 1234 | -18 | -13 | -2 | 4.28 | 0.009* |
Sub-lobar, Extra-Nuclear, WM, Internal capsule, Crus post. | l | Â | -19 | -12 | 6 | 4.13 | 0.012* |
Precentral Gyrus, WM | l | 351 | -9 | -25 | 65 | 4.27 | 0.009* |
Precentral Gyrus, subgyral, WM, Corona radiata | l | 1148 | -37 | -11 | 43 | 4.16 | 0.011* |
Precentral Gyrus, subgyral, WM, Corona radiata | l | Â | -28 | -25 | 50 | 4.16 | 0.012* |
Precentral Gyrus, subgyral, WM, Corona radiata | l | Â | -25 | -22 | 42 | 4.06 | 0.012* |
subgyral, WM, Corona radiata, below BA 6 | l | 241 | -13 | -14 | 59 | 4.08 | 0.014* |