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Table 1 Parent and product ion transitions used for analysis by mass spectrometry

From: In vitro study of uptake and synthesis of creatine and its precursors by cerebellar granule cells and astrocytes suggests some hypotheses on the physiopathology of the inherited disorders of creatine metabolism

 

Parent ion

m/z

Product ion

m/z

LOD

(nmol/L)

LOQ

(nmol/L)

Gly

132.1

76.1

-

-

[13C2,15N]Gly

135.1

78.6

8

30

Arg

231.2

70.2

-

-

[15N2]Arg

233.2

70.2

24

26

GAA

174.1

101.1

-

-

[1,2-13C2,15N3]GAA,

179.1

105.0

30

50

Cr

188.1

90.1

-

-

[1,2-13C2,15N3]Cr

193.1

93.1

5

8

D3Cr

191.2

93.1

2

3

[1,2-13C2]GAA (IS)

176.1

103.1

-

-

  1. Parent and product ion transitions used in MRM and lower detection and quantitation limits are reported. The LOD and LOQ were estimated analyzing ten blank samples and were calculated adding to the mean concentration respectively 3 and 10 SD.