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Table 3 Effects of 10 μM CCh, 2 μM AFDX, or co-application of CCh and AFDX as indicated on the maximal amplitude of the field potentials, the maximal amplitude of EPSP (EPSP max ), the I 50 and slope factor of the EPSP input–output curve

From: Distinct muscarinic acetylcholine receptor subtypes mediate pre- and postsynaptic effects in rat neocortex

 

Ctl (n = 8)

CCh (n = 8)

CCh + AFDX (n = 8)

Field max (mV)

−0.36 ± 0.09

−0.1 ± 0.04 (*)

−0.26 ± 0.08 (*) (+)

EPSP max (mV)

18.9 ± 1.8

10.9 ± 1.6 (*)

15.2 ± 1.7 (*) (+)

I 50 (V)

8.45 ± 0.7

10.9 ± 0.86 (*)

9.65 ± 0.8 (*)

Slope factor

2.29 ± 0.27

3.27 ± 0.48 (*)

2.70 ± 0.33 (*)

 

Ctl (n = 7)

AFDX (n = 7)

AFDX + CCh (n = 7)

Field max (mV)

−0.79 ± 0.17

−0.99 ± 0.24

−0.67 ± 0.23

EPSP max (mV)

22.2 ± 2.4

23.9 ± 1.8 (*)

23 ± 1.8

I 50 (V)

7.42 ± 1.11

7.22 ± 1.44

8.94 ± 2.37

Slope factor

1.82 ± 0.67

2.05 ± 0.71

3.07 ± 0.75 (*) (+)

  1. The order of two drugs given in the figures indicates the sequence of application (i.e. “CCh + AFDX” means AFDX was added to a CCh containing ACSF and vice versa)
  2. These experiments were performed in STRC
  3. *: p < 0.05 vs. control, +: p < 0.05 vs. previous condition