Figure 2

Enhanced RGC survival does not occur in Wld^Stransgenic rats after optic nerve crush and lens injury. (A) Percentage of surviving RGC (compared to control) 14 days after either optic nerve crush alone or in combination with lens injury in adult wildtype and Wld^S transgenic rats. Significant differences are indicated by asterisk (P < 0.01 = **). Cross-sections through adult wildtype or Wld^S retinae stained for Islet-1 (to identify RGC in the ganglion cell layer) from (B, C) control (untreated), or 14 days after (D, E) optic nerve crush, or (F, G) optic nerve crush in combination with lens injury. GC = Ganglion cell layer; IP = Inner plexiform layer; IN = Inner nuclear layer; WT = Wildtype; ONC = Optic nerve crush; ONC + LI = Optic nerve crush + lens injury; Scale bars: 50 μm