Table 3 Pathways involving monocytic genes expressed by AMC
Pathway | Nr. of Genes | P-Value | Benjamini corrected P-value |
|---|---|---|---|
REACT_17015:Metabolism of proteins | 37 | 2.00E-16 | 1.20E-14 |
REACT_71:Gene Expression | 42 | 3.30E-13 | 8.60E-12 |
REACT_1762:3′ -UTR-mediated translational regulation | 24 | 6.20E-13 | 1.10E-11 |
Ribosome | 17 | 1.30E-10 | 1.40E-08 |
REACT_6167:Influenza Infection | 24 | 1.90E-09 | 2.50E-08 |
Proteasome | 10 | 1.20E-06 | 6.90E-05 |
Pathogenic Escherichia coli infection | 10 | 6.70E-06 | 2.50E-04 |
P00029:Huntington disease | 16 | 7.20E-06 | 5.80E-04 |
REACT_13635:Regulation of activated PAK-2p34 by proteasome mediated degradation | 10 | 1.50E-05 | 1.50E-04 |
P00049:Parkinson disease | 12 | 3.40E-05 | 1.40E-03 |
REACT_9035:APC/C:Cdh1-mediated degradation of Skp2 | 11 | 3.80E-05 | 3.30E-04 |
REACT_6850:Cdc20:Phospho-APC/C mediated degradation of Cyclin A | 11 | 7.60E-05 | 5.70E-04 |
REACT_6185:HIV Infection | 18 | 1.70E-04 | 1.10E-03 |
REACT_11045:Signaling by Wnt | 10 | 2.20E-04 | 1.30E-03 |
P00016:Cytoskeletal regulation by Rho GTPase | 10 | 1.40E-03 | 3.70E-02 |
Fc gamma R-mediated phagocytosis | 9 | 1.90E-03 | 5.10E-02 |
P00018:EGF receptor signaling pathway | 11 | 2.40E-03 | 4.80E-02 |
P00034:Integrin signalling pathway | 14 | 2.70E-03 | 4.20E-02 |
Neurotrophin signaling pathway | 10 | 2.70E-03 | 6.00E-02 |
P00060:Ubiquitin proteasome pathway | 8 | 4.30E-03 | 5.70E-02 |
REACT_578:Apoptosis | 12 | 4.90E-03 | 2.50E-02 |
Chemokine signaling pathway | 12 | 4.90E-03 | 8.80E-02 |
REACT_1538:Cell Cycle Checkpoints | 11 | 5.30E-03 | 2.50E-02 |
P00021:FGF signaling pathway | 10 | 5.80E-03 | 6.50E-02 |
REACT_383:DNA Replication | 10 | 6.20E-03 | 2.70E-02 |