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Table 2 Effects of SDZ Ser 082 and SB 206553 on motor activity

From: SB 206553, a putative 5-HT2C inverse agonist, attenuates methamphetamine-seeking in rats

 

Horizontal Activity

Total Distance

Vertical Activity

Vehicle

727 ± 85

189 ± 66

46 ± 10

1.0 mg/kg SDZ

572 ± 164

182 ± 65

88 ± 32

Vehicle

634 ± 66

186 ± 63

37 ± 14

5.0 mg/kg SB206

564 ± 132

107 ± 34

9 ± 3

Vehicle

379 ± 97

82 ± 42

32 ± 11

10.0 mg/kg SB206

453 ± 41

132 ± 30

11 ± 5

  1. Rats that had undergone repeated cue reactivity testing were withdrawn from methamphetamine and assessed for motor effects after pretreatment with 1.0 mg/kg SDZ Ser 082 (SDZ; 5-HT2C receptor antagonist), 5.0 mg/kg SB 206553 (SB206; putative 5-HT2C receptor inverse agonist), 10.0 mg/kg SB206 and respective vehicles. Serotonin2C receptor antagonism and inverse agonism had no effect on motor activity.
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BMC Neuroscience

ISSN: 1471-2202

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