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Table 3 Functional Activations for High-Calorie, Low-Calorie and Non-Food Object Contrasts at Post-Treatment in Obese Endometrial Cancer Patients Enrolled in a 16-Session Group Behavioral Lifestyle Intervention

From: Reduction in neural activation to high-calorie food cues in obese endometrial cancer survivors after a behavioral lifestyle intervention: a pilot study

 

   Brain Region (Hemisphere)

Pre-Meal (Fasted)

Post-Meal (Fed/Satiated)

Peak Voxel

cPeak Voxel

x

y

z

Cluster Size*

t

x

y

z

Cluster Size*

t

↑ Activation

High Calorie vs. Low Calorie Food

 

   Declive

-48

-83

-20

457

8.70

     
 

   Declive

-19

-64

-9

233

4.87

     
 

   Inferior Frontal Gyrus (BA = 46)

     

44

38

12

907

8.97

 

   Middle Frontal Gyrus (BA = 9)

     

41

18

31

575

9.75

 

   Middle Frontal Gyrus (BA = 10)

     

40

62

8

479

12.5

 

   Anterior Cingulate (BA = 32)

     

-16

44

-4

403

7.63

 

   Insula (BA = 13)

     

42

11

0

182

5.94

 

High Calorie vs. Non-Food Object

 

   Culmen (BA = 10)

-4

-57

2

196

5.04

     
 

   Middle Frontal Gyrus (BA = 6)

-53

7

44

171

4.60

     
 

Low Calorie vs. Non-Food Object

 

   No regions survived threshold

          

↓ Activation

High Calorie vs. Low Calorie Food

 

   Medial Frontal Gyrus (BA = 10)

5

55

12

292

-9.68

     
 

High Calorie vs. Non-Food Object

 

   Precentral Gyrus (BA = 4)

48

-6

42

379

-4.86

     
 

   Caudate Tail

     

18

-37

20

735

-10.7

 

   Claustrum

     

29

-20

16

492

-7.36

 

Low Calorie vs. Non-Food Object

 

   Culmen

9

-58

-8

457

-7.76

     
 

   Declive

22

-60

-13

680

-8.40

     
 

   Cingulate Gyrus (BA = 31)

     

-8

-23

43

672

-11.6

 

   Postcentral Gyrus (BA = 3)

     

-56

-10

22

701

-15.3

 

   Insula (BA = 13)

     

-34

-15

21

839

-11.3

 

   Anterior Cingulate (BA = 24)

     

-9

32

13

516

-8.84

 

   Medial Frontal Gyrus (BA = 10)

     

-7

55

12

640

-8.46

  1. x, y, z = coordinates in Talairach space; t statistic for peak voxel; *Cluster size is reported in mm3. Results are whole brain cluster corrected for multiple comparisons; threshold α < 0.05 (min. cluster size: 6-38 voxels).