Validation of voltage-dependent properties in the simulations. Voltage clamp simulations with the model (left column) resulted in similar current responses as in experiments (right column, c.f. Figure 2D-F in Results). The insets on the left show the voltage protocols used. A) The current elicited from voltage jump from -117 mV prepulse up to + 3 mV. B) The current elicited by voltage jump from -57 mV prepulse up to +3 mV. C) The subtraction current A -B.