The effects of glycemic control on seizures and seizure-induced excitotoxic cell death

BMC Neuroscience

Table 1 Effect of kainic acid administration on seizure parameters in normoglycemic, hypoglycemic and hyperglycemic mice

Mouse strain	Glycemic status	Stages 1-4 (% of mice)	Stage 5 (% of mice)	Latency (min)	Duration (min)
FVB/NJ	Normoglycemic	100	96.37	32.8 ± 1.6	69.6 ± 4.7
C57BL/6	Normoglycemic	100	93.76	30.5 ± 1.3	76.3 ± 2.8
C57BL/6	Hypoglycemic	100	89.34	30.4 ± 6.4	55.4 ± 14.4
C57BL/6	Non-ketotic hyperglycemic	100	92.58	49.6 ± 6.1^a	66.2 ± 4.0
C57BL/6	STZ-hyperglycemic	100	96.08	36.5 ± 4.6	93.3 ± 2.9^b

KA induced a similar level of stage, latency and seizure duration irrespective of mouse strain. A significant difference in latency to onset of stage 4 seizures was observed in non-ketotic hyperglycemic mice as compared to normoglycemic C57BL/6 mice (^aF=7.50; P=0.03) and a significant difference in duration of stage 4/5 seizures was observed in STZ-hyperglycemic mice as compared to normoglycemic C57BL/6 mice (^bF=17.56; P=0.006).

ISSN: 1471-2202