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Inverse stochastic resonance induced by ion channel noise
© Uzuntarla et al; licensee BioMed Central Ltd. 2012
Published: 16 July 2012
Recent work has considered the inhibitory effects of noise on neuronal activity, particularly on rhythmic firing. For example, Paydarfar et al.  studied the influence of noise on neuronal pacemakers in an in vitro preparation of the squid giant axon, and found that small noisy currents induce an on-off switching behavior between two nearby regimes: repetitive firing and quiescence. They also showed that the timings of on-off switching of the pacemaker depend on the intensity and spectral properties of noisy current. Tuckwell et al. [2, 3] further investigated the inhibitory effect of noise in a single Hodgkin-Huxley neuron. These authors show that in a model neuron subject to stochastic external additive noise, the average firing rate exhibits a minimum as the noise amplitude is varied. The authors called this phenomenon Inverse Stochastic Resonance (ISR), in contrast to the well-known phenomenon of stochastic resonance.
- Paydarfar D, Forger DB, Clay JR: Noisy inputs and the induction of on–off switching behavior in a neuronal pacemaker. J Neurophysiol. 2006, 96: 3338-3348. 10.1152/jn.00486.2006.View ArticlePubMedGoogle Scholar
- Tuckwell HC, Jost J, Gutkin BS: Inhibition and modulation of rhythmic neuronal spiking by noise. Phys Rev Lett. 2009, 80: 031907-8.Google Scholar
- Tuckwell HC, Jost J: Weak noise in neurons may powerfully inhibit the generation of repetitive spiking but not its propagation. Plos Comput Biol. 1000, 6: e794-13.Google Scholar
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