Skip to main content

Advertisement

A neuromechanical computational model of spinal control of locomotion

Article metrics

  • 1076 Accesses

We developed a neuromechanical computational model of cat locomotion that simulated the locomotor movements of cat hindlimbs controlled by spinal locomotor central pattern generators (CPGs, one per limb). In the closed-loop model, CPG operation was adjusted by afferent feedback from the hindlimbs. The CPG model was based on the previous two-level model [4] and included a half-center rhythm generator (RG), producing alternating flexor and extensor activities, and a pattern formation (PF) network operating under control of RG and controlling the synergetic activities of different hindlimb motoneuron pools. This basic model [4] was extended by incorporating additional neural circuits at the PF level allowing the CPG to generate the complex activity patterns of motoneurons controlling two-joint muscles. The model included reflex circuits, mediating reciprocal inhibition between antagonistic motoneurons, recurrent inhibition of motoneurons via Renshaw cells, and di-synaptic excitation of extensors by extensor afferents during stance phase of locomotion.

The hindlimbs with the pelvis and trunk were modeled as a 10 degree-of-freedom sagittal plane system of rigid segments interconnected by frictionless revolute joints. The hindlimb interactions with the ground and other body segments were modeled as linear springs and dampers [1, 2]. The two hindlimbs were driven by 18 muscle actuators representing major hindlimb muscles in the cat. The dynamics of each muscle-tendon unit was described by a Hill-type model extended to account for muscle mass, pennation angle, and force-length-velocity properties of muscle and tendon [1, 2]. All muscles generated motion-dependent afferent signals which were calculated as functions of muscle length, velocity and force using modified regression equations from [3]. Parameters of the musculoskeletal model were identified by minimizing a mismatch between the computed (based on the recorded hindlimb muscle activity) and experimentally recorded changes in the joint angles, joint moments and ground reaction forces using the simulated annealing optimization algorithm [1, 2].

The developed neuromechanical model demonstrated stable locomotion and exhibited realistic patterns of muscle activation, limb kinematics, and ground reaction force dynamics. The model was used for investigation of the role of afferent feedback and the CPG in control of locomotion under different conditions.

References

  1. 1.

    Prilutsky BI, Klishko AN: Activity of muscle spindle and tendon organ afferents during cat locomotion computed using a musculoskeletal model. Soc Neurosci Abs. 2007, 189: 14-

  2. 2.

    Prilutsky BI, Klishko AN, Farrell B, Harley L, Phillips G, Bottasso CL: Movement coordination in skilled tasks: Insights from optimization. Advances in Neuromuscular Physiology of Motor Skills and Muscle Fatigue. Edited by: Shinohara M. 2009, Research Signpost, Kerala, India, 139-171.

  3. 3.

    Prochazka A: Quantifying proprioception. Prog Brain Res. 1999, 123: 133-142.

  4. 4.

    Rybak IA, Shevtsova NA, Lafreniere-Roula M, McCrea DA: Modelling spinal circuitry involved in locomotor pattern generation: insights from deletions during fictive locomotion. J Physiol. 2006, 577: 617-639. 10.1113/jphysiol.2006.118703.

Download references

Acknowledgements

Supported by NIH: R01 NS048844, R01 EB012855 and R01 HDO32571

Author information

Correspondence to Sergey N Markin.

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and Permissions

About this article

Cite this article

Markin, S.N., Klishko, A.N., Shevtsova, N.A. et al. A neuromechanical computational model of spinal control of locomotion. BMC Neurosci 13, P48 (2012) doi:10.1186/1471-2202-13-S1-P48

Download citation

Keywords

  • Ground Reaction Force
  • Pennation Angle
  • Hindlimb Muscle
  • Rhythm Generator
  • Afferent Feedback